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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Increasing the effectiveness of ethanol against Staphylococcus aureus (MRSA) by using Pulicariaundulata plant extract from Al Muthanna desert

Author: EMADULDEENHATEM ABED, MAYTHAMABASMAKKI, DHIFAFJABBARSHAMRAN
Abstract: A drug-resistant bacterial species that commonly causes hospital infections is becoming increasingly resistant to alcohols that used as antiseptics and disinfectants and this cause a global problem. In the present study we try to increasing the effectiveness of ethanol as antiseptic and disinfection by mixing it with Pulicaria undulata, leave and stems extracts, against MRSA. That obtain from ethanol in concentrations 100, 90 and 80% were 6,7 and 11 mm, respectively. While the lowest concentrations 10 and 20% ethanol show no effects. On the other hand the mixing of ethanol with P. undulate extracts show a significant results whereas the 100, 90 and 80% when mixed with 100, 50 and 25 mg from leaves and stems extracts were 38,33 and 30 mm for leaves, and 35, 31and 28 mm for stems, respectively. When the low concentrations of leaves and stems extracts 1.57 and 0.78 mg were mixed with ethanol show low or no inhibition zone. In addition, there is no recovery for MRSA after four days in 25, 50 and 100 mg plant extracts mixed with 100, 90, 80 and 70% ethanol. The ethanol efficiency can be increased by using the plant extract.
Keyword: ethanol,Pulicaria undulat e, MRSA, antibacterial effect.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.085
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