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Role of IL -33 Levels with HCV Genotype in Predicting Chronic Liver Disease among Iraqi Patients
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| Author:
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EKHLAS FALIH, GHANIM HUSSEIN MAJEED, AHMED ABDUL -AL-HASSAN ABBAS
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| Abstract:
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Patients who suffers from hepatitis C chronic infection have different levels of hepatic inflammatory damage and
fibrosis, with increasing risk for developing liver cirrhosis.IL-33 in liver disease has been attracted the attention of an
increasing number of researchers due to its role in the development of a variety of liver diseases. This study aimed for
examination of the potential role of IL-33 genotype with viral load in the pathogenicity of chronic liver disease among
Iraqi patients. Current study included 40 healthy controls, 65 patients suffering from chronic hepatitis C infection, 15
patients with cirrhosis and 10 with hepato cellularcarcinoma who attended to the Gastroenterology and Hepatology
Teaching Hospital in Baghdad during the period from June/2017 to February/2018.Human IL-33 estimated by ELISA
technique. The genotype of Hepatitis C virus together with the viral load were detected by Real-TM PCR. The mean
concentration of IL-33 in serum among patients with chronic hepatitis C(CHC)had significantly higher levels
compared to the control group subjects (68.90pg./ml , VS17.19 pg./ml,respectively). Actually, with no significant
differences found among patients groups (CHC, cirrhosis orhepato cellular carcinoma). Moreover, the most
prevalence genotype in this study was genotype 4 then 1a.
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| Keyword:
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Hepatitis C virus, liver cirrhosis, HCC, interleukine-33genotype and HCV RNA
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.061
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| Download:
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