IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Characterization and Evaluation of Antimicrobial and Cytotoxic Activities of Glycine max Methanol Extract

Author: HEBA ABDEL-HADYA, EMAN AHMED EL-WAKILA, SAMI MOHAMED NASRB
Abstract: Glycine max seeds use in many types of food in Egypt and all over the world. Also, it has many pharmacological properties. This study aimed to evaluate cytotoxic and antimicrobial activities of the plant extract on murine spleen cells and hepatocellular carcinoma (HepG2 cell line) as well as GC-MS analysis. The seeds were extracted with 85% methanol and tested on murine spleen cells and HepG2 cell line with different concentrations. Also, antimicrobial activity of the extract was studied by mean inhibition zone. The outcomes proved that the cytotoxic activity of the plant on murine spleen cells is very weak (380.94µg/ml) as well as on HepG2, it inhibits the cell viability% to 8.5% after 24 hrs. (IC50 = 42.5µg/ml). Also, the plant showed good antimicrobial activity in a concentration-dependent manner on fungi and bacteria (Gram positive and Gram negative). GC-MS analysis of bioactive compounds in the plant extract revealed the presence of 11 bioactive compounds. The major bioactive compounds are 9,12-octadecadienoic acid (Z,Z)-, methyl ester (41.24 %), hexadecanoic acid, methyl Ester (27.39 %), 9 octadecenoic acid (Z)-,methyl ester (16.58%), methyl stearate (4.71%), ethyl linoleate (3.92%) and n-hexadecanoic acid (2.34%). According to these finding, Glycine max methanol extract is potential as anticancer and antimicrobial agents that is may be due to the identified bioactive compoundsby GC-MS analysis. Therefore, the phytochemicals of the plant may be responsible for the various pharmacological actions.
Keyword: Antibacterial, Antifungal,GC-MS analysis, HepG2 cell line, Murine splenic cells, Soya bean
DOI: https://doi.org/10.31838/ijpr/2019.11.02.060
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
Pharmacovigilance: Current Scenario and Emerging Trends

National Conference sponsored by GUJCOST on 03.08.2019 at SNLPCP, Umrakh

Download Brochure
News & Events
0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus
Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477