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Novel and Validated First Derivative UV Spectrophotometric Method for the Determination of Tolperisone Hydrochloride in Pharmaceutical Preparations
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SANTOSH KARAJGI, SHAHID MOMIN, R.B.KOTNAL
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| Abstract:
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A simple, novel, sensitive, and specific spectrophotometric method was developed and validated for the determination of Tolperisone in bulk and its dosage form. The method is based on the first derivative UV Spectrophotometric method at an absorption maximum of 260nm using distilled water as the solvent. Beer’s law obeyed in the concentration range of 10-50 µg/ml. The recovery studies ascertained the accuracy of the proposed method and results were validated as per ICH guidelines. The results were found satisfactory and reproducible. The method was applied successfully for the estimation of Tolperisone in bulk and dosage form.
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