IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Design and Characterization of Bilayer Controlled Release Matrix Tablets of Losartan Potassium

Author: UPLOADED BY-ADMIN, DODDAYYA HIREMATH, PRAKASH GOUDANAVAR, MOHD AZHARUDDIN, RAJAGOPAL. H. UDUPI, MD. SARFARAZ
Abstract: The objective of the study was to develop and evaluate controlled release bilayer matrix tablets of losartan potassium employing xanthan gum and gum karaya as a polymers. Controlled release bilayer matrix tablets containing losartan potassium were developed using different drug: polymer concentration. Tablets were prepared by direct compression method. Differential scanning calorimetry study revealed no chemical interaction between drug and polymers used. Precompression parameters like angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio were within the limits. Post compression parameters like hardness, thickness, friability, weight variation test and drug content complied with pharmacopoeial limit for the tablets. In-vitro release studies were carried out using USP XXIV type II (paddle method) dissolution apparatus at 75 rpm by taking 900 ml of 0.1 N HCl (pH 1.2) as dissolution medium for first 2 h and later replacing it with 900 ml pH 6.8 phosphate buffer solution for rest of the time period at 37±0.5oC. The extent of swelling was measured in terms of percentage weight gain by the tablets. Percentage water uptake of bilayer matrix tablets was dependent on the concentration of the xanthan gum and gum karaya. The result of in vitro dissolution studies indicated bilayer matrix tablets containing 50% w/w of blend of xanthan gum and gum karaya (L9) has better controlled release over 24 h. The mechanism of drug release was found to be non-fickian diffusion.
Keyword: Bilayer matrix tablets, Controlled release, Losartan potassium, Natural polymers, direct compression, In vitro release.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free