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Design and Characterization of Bilayer Controlled Release Matrix Tablets of Losartan Potassium
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UPLOADED BY-ADMIN, DODDAYYA HIREMATH, PRAKASH GOUDANAVAR, MOHD AZHARUDDIN, RAJAGOPAL. H. UDUPI, MD. SARFARAZ
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| Abstract:
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The objective of the study was to develop and evaluate controlled release bilayer matrix tablets of losartan potassium
employing xanthan gum and gum karaya as a polymers. Controlled release bilayer matrix tablets containing losartan potassium
were developed using different drug: polymer concentration. Tablets were prepared by direct compression method. Differential
scanning calorimetry study revealed no chemical interaction between drug and polymers used. Precompression
parameters like angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio were within the limits. Post
compression parameters like hardness, thickness, friability, weight variation test and drug content complied with pharmacopoeial
limit for the tablets. In-vitro release studies were carried out using USP XXIV type II (paddle method) dissolution
apparatus at 75 rpm by taking 900 ml of 0.1 N HCl (pH 1.2) as dissolution medium for first 2 h and later replacing it with
900 ml pH 6.8 phosphate buffer solution for rest of the time period at 37±0.5oC. The extent of swelling was measured in
terms of percentage weight gain by the tablets. Percentage water uptake of bilayer matrix tablets was dependent on the concentration
of the xanthan gum and gum karaya. The result of in vitro dissolution studies indicated bilayer matrix tablets containing
50% w/w of blend of xanthan gum and gum karaya (L9) has better controlled release over 24 h. The mechanism of
drug release was found to be non-fickian diffusion.
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| Keyword:
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Bilayer matrix tablets, Controlled release, Losartan potassium, Natural polymers, direct compression, In vitro release.
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