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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Phytochemical Screening, In-vivo Antioxidant and hepatoprotective effect of aqueous extracts of marine brown seaweed Padina tetrastromatica

Author: RAJESHKUMAR S, BHAVANI, KOTTESWARAN
Abstract: The main objective of the study was to evaluate the hepatoprotective activity of the aqueous extracts of the Padina tetrastromatica and its leaf in validated experimental animal models. In this study, preliminary phytochemical analysis and hepatoprotective activity of the water extract of marine brown seaweed Padina tetrastromatica. The biochemicals analysis was evaluated by determining the changes in the activity of AST, ALT, gamma GT, Bilirubin, cholesterol and Total protein. It was found that water extract of P. tetrastromatica at a dose of 500 mg/kg body weight exhibited excellent protective effect by lowering the serum levels of biochemical markers to a significant extent. The changes in the antioxidant levels of Superoxide Dismutase (SOD), Catalase, Glutathione Peroxidase was performed in animal model cells. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical markers studies of blood samples of paracetamol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by paracetamol and blood samples from the animals treated with the algae extracts showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells, the extracts of algae could afford high significant dose-dependent protection against paracetamol induced hepatocellular damage.
Keyword: Padina tetrastromatica; Hepatoprotective; Antioxidant; Seaweeds
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0.12
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