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Synthesis and Anti-depressant Activity of 2-Aminothiazo1es Substituted Quinazoline Derivatives
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| Author:
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NARENDRA JOSHI, DR. ANJU GOYAL
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| Abstract:
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Our Current Study Focus on the synthesis of derivatives of Quinazoline substituted with a series of 2-aminothiazole derivatives. Eighteen on compound from the series have been synthesized, characterized and tested for in vivo (Force pool swimming method) for anti-depressant activity. Compounds QA3 and QA11 induced amazing antidepressant activity compared to standard drugs at the dose of 20 mg/kg. Other compounds QA2, QA6, QA10, and QA18 passes moderate activity against standard Fluoxetine (75.36%) and Imipramine (72.82 %) compound which is 62.75%, 60.55%, 66.30% and 60.66% respectively. Some of the compound was found good activity compared to the standard compound Fluoxetine and Imipramine.
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| Keyword:
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Quinazoline, 2-aminothiazole, and Anti-Depressant activity
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| EOI:
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| DOI:
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