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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A REVIEW ON CLINICAL MONITORING OF VARIOUS SSRI’s FOR THEIR DRUG INDUCED HYPONATREMIA IN HOSPITALIZED PSYCHIATRIC PATIENTS

Author: ANNIE ZACHARIAH, MINCY MATHEW, MATHEW GEORGE, LINCY JOSEPH
Abstract: Hyponatremia is a recognized, but rare complication of the anti depressant SSRI therapy affecting early stages of treatment which is idiosyncratic in type causing significant morbidity and mortality. The clinical monitoring of the serum natremic levels is done to identify the development of hyponatemia associated with the use of SSRI anti depressants. The mechanism of hyponatremia is thought to be the syndrome of inappropriate secretion of anti diuretic hormone. Hyponatremia and SIADH can cause such complications as seizure, coma, and rarely death for SSRI users. The need for routine electrolyte monitoring in SSRI users is justified in this review.
Keyword: Hyponatremia, SSRI, depression, SIADH
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