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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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“Retrospective Analysis on Adverse Drug Reactions Due to Antimicrobials in a Tertiary Care Hospital of Pauri Garhwal”.

Author: RANGEEL RAINA, DEEPAK DIMRI, SWATI THAPLIYAL
Abstract: Background: Adverse drug reactions have found to be a significant problem in healthcare and most of these reactions are mainly due to antimicrobials group of medicines. Objective: The present study aimed to detect and assess the incidence, pattern, clinical manifestations, and causative agents of antimicrobial induced Adverse drug reactions (ADRs) in hospitalized patients. Methodology: A retrospective study to analyze the clinical and epidemiological variables on the all suspected cases of ADRs due to antimicrobial reported in the various out-patient departments and in-patients for last four years. Results: Out of 426 reported ADR cases in last four years, 161 (37.8%) were found to be due to antimicrobials. Mean age of patients suffering from antimicrobial induced ADRs was 33.93 years and maximum number of ADRs were reported in the age group of 20-39 years (67,41.6.%). Females were affected more than males (W: M:: 92:69 , 57.2%::42.8%). Maximum number of affected patients (117, 72.7%) recovered within seven days and 115 (71.43%) cases recovered without any intervention. Maximum number of antimicrobial induced ADRs were reported by department of Medicine (75, 46.6%), followed by Dermatology (36, 22.36%) and Surgery (29, 18.01%). Amongst AMAs, betalactams (56, 34.8%) and quinolones (28, 17.4%) were the most frequent culprits followed by aminoglycosides (26, 16.2%). Most common organ system involved was dermatological (112, 69.6%), followed by gastrointestinal (24, 14.9%). Conclusion: Antimicrobial induced adverse drug reactions are significant problem in healthcare which may be responsible for increased healthcare cost and increased hospital stay.
Keyword: Adverse Drug Reactions; Antimicrobials, Pharmacovigilance, prevalence
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