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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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SYNTHESIS OF SOME NOVEL {1[(1PHENYLETHYLIDENE) AMINO] NAPHTHO [2,1-b]FURAN-2- YL}4-SUBSTITUTED PYRIMIDIN-2-AMINE DERIVATIVES FOR THEIR ANTIOXIDANT ACTIVITY.

Author: RIDDHI MADHU, T.Y.PASHA, SANDIP PATEL
Abstract: 4-{1- [(1-phenylethylidene) amino] naphtha [2,1-b] furan-2-yl} 4-(4- substituted) pyrimidin-2-amine derivatives(4a-4j) were synthesized by the cyclization of guanidine and various chalcones(3) which were synthesized by the condensation of 1-(1-{[(1Z)-1-phenylethylidene]amino}naphtho[2,1-b]furan-2-yl)ethanone(2) with various substituted aromatic aldehydes. 1-(1-{[(1Z)-1-phenylethylidene]amino}naphtho[2,1-b]furan-2-yl)ethanone(2) were synthesized bythe condensation of 1-(1-aminonaphtho[2,1-b]furan-2-yl)ethanone(1) with acetophenone. The startingmaterial2-hydroxy-1-naphthonitrile was treated with chloroacetone and anhydrous potassium carbonate to give 1-(1-aminonaphtho[2,1-b]furan-2-yl)ethanone(1). All newly synthesized compounds has been developed under conventional heating and microwave irradiation.The structures of the newly synthesized compounds were established on the basis of elemental and spectral (IR, 1H NMR and Mass) studies. Further newly synthesized compounds were showed moderate to potent antioxidant activity.
Keyword: Pyrimidine-2-amine, Antioxidant activity.
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