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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NOVEL 2-AMINO-4-(SUBSTITUTED)-6-SUBSTITUTEDPHENYL-4H-PYRAN-3-CARBONITRILE BEARING DIFFERENT HETEROCYCLES

Author: LOHAR S, VINOD TUKARAM, KETAN GANURE, K. S. LOHAR
Abstract: Heterocyclic compounds have captured our attention for many reasons, chief among them are their various biological properties. The emergence and spread of antimicrobial resistance has become one of the most serious public health concern across the world. In recent years, pyranes and their derivatives have attracted serious interest due to their useful biological activities such as antibacterial, antifungal, antioxidant, cosmetics, pigments, anti-inflammatory, antipyretic, antiviral, anticancer and anticoagulant, etc. Also, 4H-pyran derivatives constitute a useful class of heterocyclic compounds which are widely distributed in nature and used in the treatment of asthma and allergies. Pyrazoles, quinoline, salicyaldehyde, pyran and pyranopyrimidine were known for their promising biological activities such as antimicrobial, antioxidant, anti-inflammatory, anticancer and antiviral activities etc. In continuation of our research on the synthesis of biologically potent 4-amino/oxo-5-substituted-7-phenylpyrido[2,3-d]pyrimidine analogues linked to different heterocyclic system, in the present study envisaged the development of some novel pyrano[2,3-d]pyrimidin-2(5H) derivatives bearing various heteroycles. These compounds were screened for their antibacterial and antifungal activities.
Keyword: Pyranopyrimidines, Pyrazole, Quinoline, Pyran, Antibacterial activity and Antifungal activity,
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0.12
2018CiteScore
 
8th percentile
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