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A Convenient Method for Synthesis and Purification of N-Desmethylmianserin-An Active Metabolite of Mianserin
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| Author:
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UPLOADED BY-ADMIN, CHAUHAN B, VASU KK, SUDARSANAM V
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| Abstract:
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N-Desmethylmianserin is a pharmacologically active metabolite of mianserin. A new method was developed to
synthesize N-Desmethylmianserin from mianserin using 1-chloroethylchloroformate. This reaction ended with the mixture
of N-Desmethylmianserin and mianserin. The N-Desmethylmianserin hydrochloride was separated from starting compound
using novel approach of selective derivatization.
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| Keyword:
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Mianserin, N-desmethylmianserin, Antidepressant
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| EOI:
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-
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| DOI:
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-
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| Download:
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