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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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High Performance Thin Layer Chromatographic Determination of Ethinylestradiol and Levonorgestrel in Combined Tablet Dosage Form

Author: UPLOADED BY-ADMIN, PADMANABH DESHPANDE, SANTOSH GANDHI, NILESH GAIKWAD, VISHAL MHATRE, JITESH PARAB
Abstract: A simple, accurate and validated high performance thin layer chromatographic (HPTLC) method for determination of Ethinylestradiol and Levonorgestrel in combined tablet dosage form has been developed. The mobile phase selected was n- Hexane: Ethyl acetate: Triethylamine (8: 2: 0.5 v/v/v) with UV detection at 220 nm. The retention factor for Ethinylestradiol and Levonorgestrel were found to be 0.19 ± 0.10 and 0.50 ± 0.12. The method was validated with respect to linearity, accuracy, precision and robustness. Results found to be linear in the concentration range of 200-1000 ng/band for Ethinylestradiol and 1000-5000 ng/band for Levonorgestrel. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The % assay (Mean ± S.D.) was found to be 98.82 ± 0.14 for Ethinylestradiol and 99.12 ± 0.11 for Levonorgestrel.
Keyword: Ethinylestradiol, Levonorgestrel, High Performance Thin Layer chromatography, Tablet dosage form
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