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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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FORMULATION AND EVALUATION OF HYPOGLYCEMIC TEA (D-TEA) IN ORAL GLUCOSE TOLERANCE TEST AND STREPTOZOTOCIN-INDUCED DIABETIC RAT MODEL

Author: SAM JOHNSON CHANDER, SANDRA CELINE, SHAWN TOMY, UJWALA TK, SAM JOHNSON UDAYA
Abstract: Objective: D-Tea is a hypoglycemic tea containing polyherbal mixture of Vetiveria zizanioides (root), Hemidesmus indicus (rhizome), Strychnos potatorum (seed), Salacia reticulata (bark), Holarhena antidysenterica (seed), Cassia auriculata (bark), Trigonella graecum (seed) and Acacia catechu (bark) and each individual herb has scientific background in treating diabetes. Aim of the study: This study aimed to formulate and evaluate the hypoglycemic effects of D-Tea, an indigenous polyherbal tea formulation, on blood glucose levels in normal and streptozotocin-induced diabetic rats. Materials and methods: D-Tea was made by blending powdered polyherbal mixture containing all the eight herbal drugs mentioned above with markedly available BoP grade leaf tea. Type 1 diabetes mellitus was induced by administering a single i.p. injection of Streptozotocin 60 mg/kg. One week after administration of streptozotocin injection, animals showing glycosuria (fasting blood sugar level >200 mg/dL) were considered as diabetic. The hypoglycemic activity and glucose tolerance test were studied in normal and Streptozotocin-induced diabetic rats after administration of D-Tea, which contains 200 & 300 mg/kg dose of anti-diabetic polyherbal mixture. Blood glucose was determined by a glucose monitor. Results: D-Tea showed a good hypoglycemic activity at a dose of 200 and 300 mg/kg p.o. of polyherbal powder at a varying degree of significance (P<0.05-0.001) in normal rats and diabetic rats in comparison with respective control group. Maximum effect of D-Tea treatment in the glucose tolerance test occurred at 120th minute of glucose administration in normal rats. The effective dose was found as 300 mg/kg. Conclusions: The extract of D-Tea significantly reduced the blood glucose level and was found to possess curative effects on experimentally produced diabetes in rats.
Keyword: polyherbal, glucose tolerance test, D-Tea, hypoglycemic, streptozotocin.
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0.12
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