IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Anticonvulsant activity of ethanol and aqueous extract of Maerua oblongifolia (Forsk.) A. Rich. root in albino mice

Author: KAMATCHI SUNDARA SARAVANAN, VARADHARAJAN MADHAVAN
Abstract: Objective: The aim of this study was to investigate the anticonvulsant effect of Maerua oblongifolia (Forsk.) A. Rich. (Capparaceae). Materials and Methods: M. oblongifolia is a woody climber commonly known as earth sugar root in English is used as one of the botanical sources for Murva, a drug in Ayurveda. Traditionally the formulations containing Murva have been used in the treatment of various ailments including neurological disorders. In this study, anticonvulsant effect of ethanol and aqueous extracts of M. oblongifolia root at 200 and 400 mg/kg, p.o were evaluated by employing Maximal Electrical Shock (MES) and Pentylenetetrazole (PTZ) induced seizure model in Swiss Albino mice. Results: The preliminary phytochemical analysis of the extracts revealed the presence of fixed oils, fats, phytosterols, alkaloids, saponins, carbohydrates, proteins and amino acids. The extracts significantly reduced the extensor phase, recovery time in MES induced seizures and delayed the onset of convulsion, reduced the recovery time in PTZ induced seizures compared to control. Conclusion: The anticonvulsant activity exerted by both the extracts was found to be dose dependent and may be due to the presence of phytoconstituents like alkaloids and saponins in the roots of M. oblongifolia as reported earlier with other plant extracts.
Keyword: Murva, Maerua oblongifolia, Anticonvulsant, Maximal Electrical Shock, Pentylenetetrazole.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free