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Anticonvulsant activity of ethanol and aqueous extract of Maerua oblongifolia (Forsk.) A. Rich. root in albino mice
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| Author:
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KAMATCHI SUNDARA SARAVANAN, VARADHARAJAN MADHAVAN
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| Abstract:
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Objective: The aim of this study was to investigate the anticonvulsant effect of Maerua oblongifolia (Forsk.) A. Rich. (Capparaceae).
Materials and Methods: M. oblongifolia is a woody climber commonly known as earth sugar root in English is used as one of the botanical sources for Murva, a drug in Ayurveda. Traditionally the formulations containing Murva have been used in the treatment of various ailments including neurological disorders. In this study, anticonvulsant effect of ethanol and aqueous extracts of M. oblongifolia root at 200 and 400 mg/kg, p.o were evaluated by employing Maximal Electrical Shock (MES) and Pentylenetetrazole (PTZ) induced seizure model in Swiss Albino mice.
Results: The preliminary phytochemical analysis of the extracts revealed the presence of fixed oils, fats, phytosterols, alkaloids, saponins, carbohydrates, proteins and amino acids. The extracts significantly reduced the extensor phase, recovery time in MES induced seizures and delayed the onset of convulsion, reduced the recovery time in PTZ induced seizures compared to control.
Conclusion: The anticonvulsant activity exerted by both the extracts was found to be dose dependent and may be due to the presence of phytoconstituents like alkaloids and saponins in the roots of M. oblongifolia as reported earlier with other plant extracts.
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| Keyword:
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Murva, Maerua oblongifolia, Anticonvulsant, Maximal Electrical Shock, Pentylenetetrazole.
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