IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Design & Formulation of Twice Daily Nifedipine Sustained Release Tablets Using EC & HPMC E15

Author: THEERDHALA KRISHNA, DR.M.SREENIVASULU, MD.NAYEEM, SK.MUBASHIRA, M.SAI GIRIDHAR
Abstract: In the present study, Nifedipine was chosen as a model drug which is an Anti-Hypertensive. Because of its short life (2hr) and its high water solubility it was chosen as a suitable candidate for sustain release matrix tablet formulation. It was formulated in to matrix tablet using hydrophilic polymer such as HPMC E15 and Ethyl cellulose as releases retardants. All the precompressional parameters (angle of repose, Hausner’s ratio and Carr’s index) were found to be within the standard limits. Tablets were evaluated for hardness, friability, thickness, drug content, in-vitro release. The effect of polymer concentration binary polymer mixture on drug release profile was studied. It was observed that the polymer concentration has influence the drug release from matrix tablet. Matrix tablet content a blend of HPMC E15 and ethyl cellulose successfully sustained the release of Nifedipine for a period of 12hr. Precompressional parameter indicated that granules used for preparing tablets with free flowing. Postcopmressional parameters (hardness, friability, thickness and drug content) were within the acceptable limit. The sustained release from ethyl cellulose and HPMC E15 was due to interaction between ethyl cellulose chain ionic polymer and HPMC chain, non-ionic polymer, which resulted in favorable increase in the water uptake capacity and gel viscosity, leading to better control the release of Nifedipine. The study indicates that the hydrophilic matrix tablets of Nifedipine prepared using HPMC E15 and Ethyl cellulose can successfully be employed as twice-a-day oral sustained release dosage form in order to improve patient compliance.
Keyword: Nifedipine, Sustained release, Matrix Tablets, Twice Daily.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free