|
Design & Formulation of Twice Daily Nifedipine Sustained Release Tablets Using EC & HPMC E15
|
|
| Author:
|
THEERDHALA KRISHNA, DR.M.SREENIVASULU, MD.NAYEEM, SK.MUBASHIRA, M.SAI GIRIDHAR
|
| Abstract:
|
In the present study, Nifedipine was chosen as a model drug which is an Anti-Hypertensive. Because of its short life (2hr) and its high water solubility it was chosen as a suitable candidate for sustain release matrix tablet formulation. It was formulated in to matrix tablet using hydrophilic polymer such as HPMC E15 and Ethyl cellulose as releases retardants. All the precompressional parameters (angle of repose, Hausner’s ratio and Carr’s index) were found to be within the standard limits. Tablets were evaluated for hardness, friability, thickness, drug content, in-vitro release. The effect of polymer concentration binary polymer mixture on drug release profile was studied. It was observed that the polymer concentration has influence the drug release from matrix tablet. Matrix tablet content a blend of HPMC E15 and ethyl cellulose successfully sustained the release of Nifedipine for a period of 12hr. Precompressional parameter indicated that granules used for preparing tablets with free flowing. Postcopmressional parameters (hardness, friability, thickness and drug content) were within the acceptable limit. The sustained release from ethyl cellulose and HPMC E15 was due to interaction between ethyl cellulose chain ionic polymer and HPMC chain, non-ionic polymer, which resulted in favorable increase in the water uptake capacity and gel viscosity, leading to better control the release of Nifedipine. The study indicates that the hydrophilic matrix tablets of Nifedipine prepared using HPMC E15 and Ethyl cellulose can successfully be employed as twice-a-day oral sustained release dosage form in order to improve patient compliance.
|
| Keyword:
|
Nifedipine, Sustained release, Matrix Tablets, Twice Daily.
|
| EOI:
|
-
|
| DOI:
|
-
|
| Download:
|
Request For Article
|
|
|