IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Tyrosinase Inhibition Activity Assay and Identification of Chemical Compounds of the Most Active Extract and Fraction of Johar (Cassia siamea Lam.) Leaves and Stem Bark

Author: BERNA ELYA, RANI SAURIASARI, VINCENT CS, NURIZA U.A
Abstract: Tyrosinase inhibitors are compounds regulating the metabolism of melanin. It is often used as an agent for preventing hyperpigmentation and whiten the skin in cosmetic products. An extract from Trengguli (Cassia fistula L.) had been known to have inhibitory activity againts tyrosinase. This study aims to determine the percent inhibition of extracts and fractions of leaves and stem bark of johar (Cassia siamea Lam.). Three extracts of johar, n-hexane, ethyl acetate, and methanol extract on final concentration 250 ppm were tested;. An extract with the highest inhibition activity was fractionated by vacuum column chromatography. Fractions were obtained tested on final concentration 250 ppm. The result showed that the methanol extract gave the highest inhibitory activity for both part of the plant, for leaves extract with IC50 values 170.27 µg/mL and the most active fraction with IC50 value 482,36 µg/mL. Whereas the stem bark extract with inhibitory percentage 22,57% and the most active fractions with inhibitory percentage 19,19%.
Keyword: Cassia siamea Lam., hyperpigmentation, inhibition, johar, leaves, stem bark, tyrosinase
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free