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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Drug Design, Synthesis And Screening Of Pyrazolo Cinnoline Derivatives As Potent Anti Tubercular Agent

Author: SULTAN UNNISSA, T.K.RAVI
Abstract: Pyrazolo Cinnolines are obtained by diazotization of substituted anilines followed by coupling to form corresponding hydrazones which on Intramolecular cyclisation forms 3-acetyl- substituted-cinnolin-4-ones. Further, treatment with hydrazine hydrate yields the expected 3’-methyl-substituted-pyrazolo Cinnoline derivatives. The compounds were characterized by analytical techniques like TLC, UV, IR, NMR Spectral studies. All the synthesised compounds were checked for drug likeliness using QIKPROP software and found to be efficacious and screening for anti-tubercular activity. All the synthesised compounds shows anti tubercular activity in comparison to standard drug
Keyword: Pyrazolo Cinnoline, Cinnoline, qikprop, anti tubercular activity, MABA
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