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Synthesis of (2e) - 1, 3-Diphenyl-2-Propene-1-One Derivatives and Evaluation of its Antioxidant and Anti-Parkinsonism Activity
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| Author:
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UPLOADED BY-ADMIN, MAHAJAN SK, PATIL CB
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| Abstract:
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Chalcones are (2E)-1,3-diphenyl-2-propen-1-one, in which two aromatic rings are linked by a three carbon and a, ?-
unsaturated carbonyl system. The present study was conducted to synthesize chalcones by base catalyzed and acid catalyzed
condensation, to evaluate their in-vitro antioxidant activity by DPPH (Diphenyl Phenyl Hydrazine) method and in-vivo antiparkinson
activity by haloperidol induced catalepsy model. The result showen that, base catalyzed condensation of chalcones
is more effective as compared to acid catalyzed condensation with respect to time, yield and purity. The titled compounds
exhibited well defined antiparkinson activity in in-vivo model.
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| Keyword:
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Chalcones, Antioxidant activity, Anti-parkinsonism activity, DPPH, Haloperidol Induced Catalepsy
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| EOI:
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| DOI:
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| Download:
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