IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

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Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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In vitro sustained release study of Thymol from Sodium Alginate Beads synthesized by Emulsion Microencapsulation

Author: YASHAWANT BHALERAO, SHRIKANT J. WAGH
Abstract: The main objective of this work was to study the effect of concentration of thymol, sodium alginate, stirring speed on synthesis, and sustained release properties of thymol loaded sodium alginate beads using emulsion microencapsulation technique. For optimization method, the statistical design approach of Plackett–Burman factorial design (PBD) of experiment was performed using Design-Expert® (DoE) software (Version- 9.0.3.1, Stat-Ease Inc., Minneapolis, MN). Preparation of thymol loaded calcium chloride – sodium alginate beads was carried out using the emulsion microencapsulation technique. No chemical interaction between thymol and sodium alginate was found in FTIR study and beads obtained were spherical and distinct in nature. Formulation showed that microencapsulation method gives sustained action in in-vitro release. Formulation shows maximum 95.18±0.43 % drug release in 12 h. Thymol loaded sodium alginate beads can be successfully prepared by emulsion microencapsulation method without any incompatibility. This study observed that the emulsion method gives promising results for sustained delivery of thymol.
Keyword: Biodegradable polymers, Plackett–Burman design, Sodium alginate beads, Thymol
DOI: https://doi.org/10.31838/ijpr/2019.11.02.064
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477