|
In vitro sustained release study of Thymol from Sodium Alginate Beads synthesized by Emulsion Microencapsulation
|
|
| Author:
|
YASHAWANT BHALERAO, SHRIKANT J. WAGH
|
| Abstract:
|
The main objective of this work was to study the effect of concentration of thymol, sodium alginate, stirring speed on
synthesis, and sustained release properties of thymol loaded sodium alginate beads using emulsion microencapsulation
technique. For optimization method, the statistical design approach of Plackett–Burman factorial design (PBD) of
experiment was performed using Design-Expert® (DoE) software (Version- 9.0.3.1, Stat-Ease Inc., Minneapolis, MN).
Preparation of thymol loaded calcium chloride – sodium alginate beads was carried out using the emulsion
microencapsulation technique. No chemical interaction between thymol and sodium alginate was found in FTIR study
and beads obtained were spherical and distinct in nature. Formulation showed that microencapsulation method gives
sustained action in in-vitro release. Formulation shows maximum 95.18±0.43 % drug release in 12 h. Thymol loaded
sodium alginate beads can be successfully prepared by emulsion microencapsulation method without any
incompatibility. This study observed that the emulsion method gives promising results for sustained delivery of
thymol.
|
| Keyword:
|
Biodegradable polymers, Plackett–Burman design, Sodium alginate beads, Thymol
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2019.11.02.064
|
| Download:
|
Request For Article
|
|
|