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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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ASSAY OFAMLODIPINE AND CELECOXIB IN COMBINATION IN THE PRESENCE OF THEIR DEGRADANTS BY STABILITY INDICATING HPLC METHOD

Author: RAMA K, RAJA S
Abstract: New combination, amlodipine and celecoxib, was approved for treating patients with osteoarthritis pain and increased blood pressure. This investigation was performed to develop and validate a stability indicting HPLC method for simultaneous assay of amlodipine and celecoxib. Chromatographic conditions for separating and analyzing amlodipine and celecoxib in the presence of their forced degradants was achieved by using a Kromasil C18 analytical column (250 mm × 4.6 mm, 5 µm) and mixture of 0.1M K2HPO4:methanol in the proportion of 60:40 (v/v) with pH 6.0 as mobile phase with a flow rate of 1 ml/min. the detection was done using photodiode array detector at 242 nm. Regression analysis confirmed a fine correlation for amlodipine and celecoxib in the range of 5-15 µg/ml and 100-300 µg/ml, respectively. The parameters like, system suitability, selectivity, sensitivity, precision, accuracy and robustness were validated. The values of validation parameters were satisfactory. Stability studies were carried out by exposing amlodipine and celecoxib standard solution to different ICH stress conditions. The results showed that no interference of degradants with the developed method.
Keyword: amlodipine, celecoxib, osteoarthritis, hypertension, HPLC analysis
DOI: https://doi.org/10.31838/ijpr/2019.11.02.057
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0.12
2018CiteScore
 
8th percentile
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477