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Saponins Role Of Bali Andong Leaf As Antiobesity In Rats
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| Author:
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N. BOGORIANI, A. A. I. M. LAKSMIWATI, A. A. B. PUTRA, W. E. HELTYANI, K. D. P. LESTARI, P. A. E. MAHAYANI
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| Abstract:
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High fat diet is one of the causes of obesity. Saponins are surface active compounds which can inhibit the absorption
of lipid in the intestine. This study aimed to observe saponin activity of andong leave as antiobesity in rats.This study
used 24 male Wistar rats, then divided into 2 groups: six rats were normal with a standard diet of laboratory and 18
rats were obese induced by high-fat diet. Then were divided into 3 groups high-fat diet, high-fat diet plus a saponin
extract 100 mg / kg and high-fat diet plus gemfibrozil 100 mg / kg. Saponin and gemfibrozil treatment were done for
30 d. Changes in body weight, Lee Obesity Index, circumference waist, daily diet intake, and number of fecal were
measured regulary the experimental periode. In vivo fecal fat and cholesterol were examined and the concentrations
of lipid profile in serum. Differences in mean levels between groups were tested by one-way ANOVA test.The results
showed a decrease in body weight, Lee Obesity Index, waist circumference, daily diet intake, and blood serum total
cholesterol, LDL cholesterol, triglycerides, and an increase in serum HDL cholesterol, daily fecal weight, total
cholesterol and fat in the feces significantly (p < 0.05) in the treatment with saponin extract of andong leaves than
high-fat groups. Based on these results were be concluded that the andong leave saponin have activity as antiobesity
and hypolipidemic.
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| Keyword:
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antiobesity, andong leaves, cholesterol, triglycerides, hypolipidemic
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.052
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| Download:
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