IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Molecular Docking and Qsar Studies of Novel 2,4 Thiazolidinedione Based Benzylamine Derivatives Against PPAR γ (1zgy) as Anti-diabetic Agents

Author: B.GEETHA , G.SWARNALATHA, G.V. SUBBA REDDY
Abstract: A sequence of novel 2,4-thiazolidinedione specified benzylamine derivatives were planned based on PASS prediction and Acute rat toxicity prediction with the help of GUSAR software. Based on the results, the designed derivatives were docked with the target protein Peroxisome Proliferator Activated Receptor Gama (PPARγ) (Pdb Id: 1ZGY). Compounds BA12, BA9 and IIBA12 were most productive in reducing the blood glucose volume in contrast to standard drug pioglitazone. In molecular docking studies BA12, BA9 and IIBA12 showed outstanding interactions with amino acids HIS 323, LYS 3367, ARG 288, CYS 285, GLU 295, MET 364, LEU 330, HIS 449, ILE 326 and PHE 363. These compounds are not showing any damage to the liver and may be treated as positive candidates for the evolution of new antidiabetis agents.
Keyword: Amino acids, PPAR?, Docking, thiazolidinedione and Benzylamine
DOI: https://doi.org/10.31838/ijpr/2019.11.02.007
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0.12
2018CiteScore
 
8th percentile
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477