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Molecular Docking and Qsar Studies of Novel 2,4 Thiazolidinedione Based Benzylamine Derivatives Against PPAR γ (1zgy) as Anti-diabetic Agents
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| Author:
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B.GEETHA , G.SWARNALATHA, G.V. SUBBA REDDY
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| Abstract:
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A sequence of novel 2,4-thiazolidinedione specified benzylamine derivatives were planned based on PASS prediction
and Acute rat toxicity prediction with the help of GUSAR software. Based on the results, the designed derivatives
were docked with the target protein Peroxisome Proliferator Activated Receptor Gama (PPARγ) (Pdb Id: 1ZGY).
Compounds BA12, BA9 and IIBA12 were most productive in reducing the blood glucose volume in contrast to
standard drug pioglitazone. In molecular docking studies BA12, BA9 and IIBA12 showed outstanding interactions with
amino acids HIS 323, LYS 3367, ARG 288, CYS 285, GLU 295, MET 364, LEU 330, HIS 449, ILE 326 and PHE 363.
These compounds are not showing any damage to the liver and may be treated as positive candidates for the
evolution of new antidiabetis agents.
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| Keyword:
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Amino acids, PPAR?, Docking, thiazolidinedione and Benzylamine
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.007
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| Download:
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