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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Intracranial meningioma association with breast carcinoma. Underlying sex hormonal effect

Author: MUHAMMED FAEADH, RAAD AHMED HUSSEIN, ASAAD F. ALBAYATI
Abstract: BACKGROUND. Meningiomas are slow growing, benign tumors originated from arachnoidal cells & attached to the dura mater & are composed of neoplastic meningothelial (arachnoidal) cells. They typically occur in adults, often women. We present a retrospective study of an association between intracranial meningioma after previous history of invasive breast carcinoma, such association is not uncommon in the literature. This current study evaluated the ocurrence of meningioma in women had invasive breast carcinoma and the influence of sex hormone and tumor receptors on meningioma growth. METHODS. In this retrospective study, we recorded 20 females patients of intracranial meningiomas ocurred after a previous history of treated invasive breast carcinoma. They were operated with craniotomy & meningioma total resection and examined for immunohistochemical estrogen & progesterone receptors. RESULTS. 65% of the meningiomas cases were progesteron receptor positive & 25% of the cases were estrogen receptors positive by immunohistochemical study. CONCLUSIONS. Meningioma is an intracranial tumor influenced by endogenous & exogenous sex hormones and may benefit from estrogen receptors modulator drugs like Tamoxifen.
Keyword: breast carcinoma, meningioma
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