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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Efficacy of intravenous paracetamol dilutions compared with lidocaine for prevention of propofol-induced pain during induction of anesthesia

Author: ALI ERDI, MAHZAD YOUSEFIAN, SARA JALDIANI
Abstract: Background: Propofol is an intravenous anesthetic drug that is commonly used for induction of anesthesia; pain during induction of anesthesia with propofol is a common problem (with a prevalence of 28-90%) that can be distressful for patients. We aimed to compare the efficiency of intravenous paracetamol in different dilutions and lidocaine in prevention of propofol-induced pain. Methods: In this randomized, double-blind clinical trial, 200 patients scheduled for elective surgery under general anesthesia with propofol was randomly assigned to 4 groups of 50 persons. In Group 1, 40 mg lidocaine in 5 ml normal saline; in group 2, 2 mg/kg Paracetamol in 5 ml normal saline; in group 3, 2 mg/kg Paracetamol in 20 ml normal saline, and in group 4, 5 ml normal saline were injected as control. Then, 25% of the calculated dose of Propofol (2.5 mg/kg) was injected at a speed of 0.5 ml/sec and the patient’s pain was determined based on VRS score from 0-3. Then, general anesthesia was induced. Results: In the four groups, there were no statistically significant differences in terms of age and sex. The amount of pain in Lidocaine group was significantly lower, compared to the control group (P=0.001), in the paracetamol group (P=0.03), in the diluted paracetamol group (P=0.009), but there was no significant difference among the three groups in terms of pain reduction. Discussion: Both 2 mg/kg paracetamol in 5 ml normal saline and in 20 ml normal saline are as effective as 40 mg lidocaine in 5 ml normal saline.
Keyword: Paracetamol ; Lidocaine ; Propofol-induced pain
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