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Study of the antimicrobial susceptibility and resistance pattern of different uropathogens in an Iranian hospitalv
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| Author:
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MARYAM MAGHBOOL, AFSANEH GHASEMI, ALI DAVOODI, ZOHREH MAKOOLATI
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| Abstract:
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Background: Urinary tract infection (UTI) is one of the most common nosocomial infections with increasing rate of
antibiotic resistance. Therefore, it is necessary to choose highly effective antibiotic with low resistance and it is only
possible by obtaining local and national guidelines for empirical therapy. This study aimed to detect the antimicrobial
susceptibility and resistance pattern of different uropathogens in Fasa hospital, in the south of Iran, from March 2016
to March 2017.
Methods: A total of 780 consecutive urine samples were cultured. The pathogens isolated were recognized using
standard methods and antibiotic susceptibility was performed by Kirby Bauer disk diffusion method. This crosssectional
study analyzed the prevalence and antibiotic resistance patterns for uropathogens based on sex, age, OPD
versus admitted patients, admitted ward and months of year.
Results: Frequency of UTI was 29% in man and 71% in woman. Outpatients were 59/9% versus 40/1% for admitted
cases. UTI was more common in teen age, Adult emergency ward and June-July months. The most common urinary
pathogen identified in all ages, sexes, wards and months were E.coli that was the most and least sensitive to
ciprofloxacin and erythromycin, respectively. The best activity in women was achieved with clindamycin and
cephalexin and in men with ciprofloxacin. Uropathogens were more resistance to cefalothin in female and to
cephalexin in male.
Conclusion: Females were nearly twice more susceptible to UTI. E. coli was the most common uropathogen.
Clindamycin and cephalexin were appropriate empirical therapy in female and ciprofloxacin in male. Cephalexin and
cefalothin were so weak for empirical choice. So, empirical treatment protocol must be based on local and national
guideline of susceptibility rates.
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| Keyword:
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antimicrobial, susceptibility, resistance, uropathogens.
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| EOI:
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| DOI:
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