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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis of Nanoencapsulation of Alpinia Galangal Extract Using Chitosan-Alginate and Cytotoxic Activity on MCF-7 Cell Lines

Author: MUHAMMAD DA’I, ERINDYAH RETNO WIKANTYASNING, AZIS SAIFUDIN, GUNAWAN SETIYADI, ARIFAH SRI WAHYUNI, AURORA MELIA, ANDI SUHENDI
Abstract: Previous research stated that Alpinia sp. of Indonesian local market has Trans p-coumaryl diacetate as anticancer. The research was aimed to formulate nanoencapsulation of Alpinia sp. extract and the cytotoxic activity on MCF-7 cell lines. The formulation of nanoencapsulation used chitosan-alginate and 1-ethyl-3-(3-dimethyl aminopropyl) carbondimides (10:1:1) as matrix. Nanoencapsulation formed was characterized by spectrophotometry UV-Vis and particle size analyzer (PSA). Drug loading (DL) and encapsulation efficiency (EE) were determined by RP-HPLC usingmethanol: water (75:25 v/v) and were monitored at the wave length of 253 nm. The result showed that the formation of nanoencapsulation was due to the particle size measured value of 264.3 ± 24.39 nm and zeta potential value of 72.33 ± 2.50 mV. The drug loading of nanoencapsulation was obtained at 0.638 ± 0.019 % with the EE value of 46.819 ± 1.381%. The nanoencapsulation of Alpinia sp. extract had cytotoxic activity on MCF-7 cell lines, IC50 value was at 168.146µg/mL equivalent to 1.075 µg/mL of coumaryl diacetate. In view of the cytotoxic activity, it could be concluded that trans p-coumaryl diacetate in nanoencapsulation form has increased the activity.
Keyword: Trans p-coumaryl diacetate, nanoencapsulation, chitosan-alginate, MCF-7.
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