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Design and Development of Sustained Release Chitosan-Bora Rice Microspheres for Targeted Drug Delivery to the Colon
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| Author:
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UPLOADED BY-ADMIN, RAMTEKE KH, BHATTACHARYA A, NATH LK
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| Abstract:
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The purpose of this research was to formulate and systematically evaluate in-vitro performances of glipizide microspheres
for targeted delivery to the colon. Glipizide microspheres containing Chitosan-bora rice were prepared by simple
emulsification phase separation technique using glutaraldehyde as a crosslinking agent.
Results of preliminary trials indicate that polymer to drug ratio and speed of rotation affected characteristics of microspheres.
The size of microspheres was found to range from 420-723 µm. The microspheres exhibited high % drug entrapment
efficiency, best batch exhibited a high drug entrapment efficiency of 57.4% and swelling index ranges from 0.73 ± 0.03
to 1.35 ± 0.15. The amount of drug release after 28 hr was found to be 64.31% ± 1.26 in PBS pH 7.4 dissolution medium and
medium with 2% cecal material 85.53% ± 1.16 drugs released within 24 hrs.
The drug release of Glipizide significantly decreased with increasing bora rice concentration this may be due to the
higher % of amylopectin present. FTIR spectra confirmed the stable character of glipizide in drug loaded microspheres. DSC
study confirmed that drug is present in the molecular dispersion. SEM indicated the surface topology of microspheres. In
vitro data obtained for colon targeting microspheres of Glipizide showed sustained drug release. Hence Bora rice may be
used as sustained release polysaccharides for colon targeting drug delivery system.
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| Keyword:
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Chitosan, Colon targeting microspheres, Glipizide, In vitro study
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| EOI:
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| DOI:
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