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Phytochemical Evaluation and Anti-Inflammatory Activity of Root and Callus Extracts of Myxopyrum smilacifolium Blume
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| Author:
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PRAVEEN P, ASHALATHA S NAIR
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| Abstract:
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Myxopyrum smilacifolium, a large woody climbing shrub belonging to the family Oleaceae is known for its medicinal properties. The present study was carried out inorder to quantify the phytochemicals of pharmacological importance and also to evaluate the anti-inflammatory potential of methanolic extracts of root and callus. The total phenol, flavonoids, tannins and alkaloids were estimated according to standard protocols. Phenols, flavonoids and alkaloids were present in high concentration in both extracts. Tannin was found to be low in roots compared to callus extracts. Human monocytic cell lines (THP1) stimulated by Lipopolysaccharide (LPS) treated with varying concentration of extracts were employed for determining the anti-inflammatory potential by assessing the inhibition of COX-2, a potent enzyme of inflammatory responses. Both extracts showed an appreciable anti-inflammatory activity when compared with the standard drug Diclofenac with root extract the maximum. The results clearly indicates that the plant is a rich source of phytochemicals and it could be correlated to its bioactivity which opens the door for future phytotherapies.
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| Keyword:
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Myxopyrum, THP1, callus, COX-2, phytochemicals
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| EOI:
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| DOI:
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| Download:
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