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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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In-Vivo and In-Vitro Evaluation of anti-obesity effect of Foieniculum vulgare Mill fruits extract

Author: CHIRAG PATEL, JALARAM H THAKKAR, DEVDAS SANTANI
Abstract: Objective: The objective of the study was to conduct a screening for potential anti-obesity effects of Foeniculum vulgare fruits (FVF) extract using a MSG-induced obese animal model, porcine pancreatic lipase assay and in-vitro proliferation assay on 3T3-L1 preadipocytes cells. Methods: FVF extract, was orally administered (287mg/kg/day and 667 mg/kg/day) for 56 days in MSG-induced obese mice, and body weight gain, food and liquid intake, glucose, plasma lipid profile, plasma leptin, adeponectin and insulin were measured. Also, potential of FVF extract on in vitro 3T3L1 pre-adipocyte differentiation and pancreatic lipase inhibition was assessed. Results: FVF extract suppressed body weight gain in a dose-dependent manner and significantly reduced white adipose tissue, plasma levels of cholesterol, triglycerides, leptin and insulin and improved plasma adiponectin levels compared with MSG-induced obese mice. We also found that FVF extract significantly inhibits the activity of pancreatic lipase and the proliferation and differentiation of 3T3-L1 cells, dose-dependent manner. Conclusions: These result suggested that Foeniculum vulgare extract would be effectively prevent obesity and hypertriglyceridemia in part through delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
Keyword: Foeniculum vulgare, pancreatic lipase, obesity
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0.12
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