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Formulation and Evaluation of Bilayer Gastroretentive Floating Tablet of Lafutidine using 32 Factorial Design
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| Author:
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RAHUL GARG, INDRAJEET SINGHVI
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| Abstract:
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The main objective of this study is to prepare a gastro retentive bilayer floating tablet of Lafutidine by direct compression technology using 32 Factorial Design and optimize concentration of polymer to give maximum retentive effect with good drug release profile. Lafutidine having biological half life (1.92 ± 0.39 hours), selected model drug as it is Competitive inhibition of histamine at H2-receptors of the gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentration reduced having first pass metabolism, low oral bioavailability, maximum absorption in the upper part of GIT hence it is suitable for gastro retentive system. In this study, a gastro retentive bilayer floating tablet was prepared which contains an immediate release portion and a floating layer. Immediate release layer prepared by superdisintegrant sodium starch glycolate, Crosspovidone and microcrystalline cellulose and Sustain release layer prepared by using hydrophilic & hydrophobic polymers such as Methocel and Carbopol. The tablets were characterized by lag time, floating time, weight variation, drug content and dissolution profile. It is concluded on the basis of buoyancy and in-vitro release kinetics that optimized formulation L-3 gave the best in-vitro release of 93.01% in 12 hrs was carried out in 1.2 pH.
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| Keyword:
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Lafutidine, Bilayer, floating tablet, Gastroretentive
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| EOI:
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| DOI:
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