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Design and Characterization of Atenolol Floating Microcapsules
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| Author:
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ANGILICAM YADAV, RAJESH KAZA
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| Abstract:
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Atenolol biodegradable floating microcapsules were prepared by feasible emulsion solvent evaporation method for a novel controlled release product in order to overcome poor bioavailability. Ethyl cellulose (1:4), HPMC (hydroxy propyl methyl cellulose) (1:4) and their combination (1:4:4) were used as coating polymers at the same concentrations in order to obtain elegant microcapsules. The formulations were characterized for size, shape, entrapment efficiency, in vitro drug release studies and were subjected to FTIR, SEM, DSC and PXRD studies. The microcapsules were discrete, large, and almost spherical and were free flowing with entrapment efficiency in the range of 89% to 94%, and size 26 µm to 55 µm. The infrared spectroscopy suggests that there was no chemical interaction between atenolol and polymers. Atenolol release from these microcapsules was slow and extended over longer periods of time depending on the polymer coat. HPMC, a hydrophilic polymer used at the ratio of 1:4 shows the release of 99.23% at the end of 12th hour which signifies the controlled release manner and better floating ability in comparison with that of EC (1:4) and in combination of ethyl cellulose and HPMC (1:4:4).
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| Keyword:
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Atenolol, Bioavailability, Controlled-release, Floating microcapsules.
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| EOI:
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| DOI:
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| Download:
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