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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Evaluation of Novel 2-oxo-3-(arylimino) Indolin-1-yl)-N-aryl acetamide Analogs as Promising Anthelmintic Agents

Author: BIPLAB DEBNATH, SWASTIKA GANGULY
Abstract: Anthelmintic resist creates a major drawback over the decades all over the world. Few drugs are regularly used in the treatment of helminth infestations in human beings as per WHO (World health Organization). In sight of this, an effort has been made to study the anthelmintic activity of some novel isatin analogs were synthesized and characterized by their spectral Analysis. All the prototypes were examined for their anthelmintic activity against african earthworms at various concentrations (5, 10 and 20 mg/mL). All compounds were tested for their beginning of paralysis time followed by time of death of worms. All the prototypes were found paralyze (vermifuge) as well as kill the earthworms (vermicidal). All prototypes at the concentration of 20 mg/mL were shown significant activity (P<0.01) with that of control. The compounds 3f, 3j and 3p were found to be comparable to that of the reference standards albendazole (20 mg/mL).
Keyword: Isatin; Synthesis; Spectral analysis; Anthelmintic activity
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