IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Hepatoprotective Activity of Ethanol and Aqueous Extract of Sansevieria roxburghiana Schult. & Schult. f. (Agavaceae) Rhizome on Carbon Tetrachloride induced Hepatotoxicity in Rats

Author: KAMATCHI SUNDARA SARAVANAN, VARADHARAJAN MADHAVAN
Abstract: Objective: To evaluate the hepatoprotective effect of ethanol and aqueous extracts of Sansevieria roxburghiana Schult. & Schult. f. (S. roxburghiana) rhizome against Carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. Materials and Methods: S. roxburghiana is considered as one of the botanical sources of the drug Murva in Ayurveda. Ethanol and aqueous extract of S. roxburghiana were prepared to perform the preliminary phytochemical study and to assess the protective activity against CCl4 induced hepatotoxicity. The rats were pretreated with ethanol and aqueous extract of S. roxburghiana (200 mg/kg and 400 mg/kg) and the standard drug, Silymarin (100 mg/kg) orally for 7 days. CCl4 was used to induce hepatotoxicity and was administered on the 7th day at a dose of 1 ml/kg (1:1 in liquid paraffin). Results: The preliminary phytochemical study revealed the presence of fixed oils, phytosterols, gums, mucilage, alkaloids, carbohydrates, saponins, proteins and volatile oil. CCl4 induced hepatic damage was evident from the altered levels of biochemical markers like Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP), total bilirubin and total protein in CCl4 treated groups. Ethanol and aqueous extract treated groups significantly reduced the SGOT, SGPT, ALP, total bilirubin and increased the total protein levels which were adversely affected in the CCl4 treated group. The biochemical findings were supported by histopathological studies of the liver sections, which revealed the hepatotoxic nature of CCl4 and the protective potential of the extracts that is comparable with the standard drug silymarin. Conclusion: This study reports the hepatoprotective potential of the rhizomes of S. roxburghiana Schult. & Schult. f.
Keyword: Murva, Hepatoprotection, S. roxburghiana, Carbon tetrachloride
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
Pharmacovigilance: Current Scenario and Emerging Trends

National Conference sponsored by GUJCOST on 03.08.2019 at SNLPCP, Umrakh

Download Brochure
News & Events
0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus
Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477