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Hepatoprotective Activity of Ethanol and Aqueous Extract of Sansevieria roxburghiana Schult. & Schult. f. (Agavaceae) Rhizome on Carbon Tetrachloride induced Hepatotoxicity in Rats
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| Author:
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KAMATCHI SUNDARA SARAVANAN, VARADHARAJAN MADHAVAN
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| Abstract:
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Objective: To evaluate the hepatoprotective effect of ethanol and aqueous extracts of Sansevieria roxburghiana Schult. & Schult. f. (S. roxburghiana) rhizome against Carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats.
Materials and Methods: S. roxburghiana is considered as one of the botanical sources of the drug Murva in Ayurveda. Ethanol and aqueous extract of S. roxburghiana were prepared to perform the preliminary phytochemical study and to assess the protective activity against CCl4 induced hepatotoxicity. The rats were pretreated with ethanol and aqueous extract of S. roxburghiana (200 mg/kg and 400 mg/kg) and the standard drug, Silymarin (100 mg/kg) orally for 7 days. CCl4 was used to induce hepatotoxicity and was administered on the 7th day at a dose of 1 ml/kg (1:1 in liquid paraffin).
Results: The preliminary phytochemical study revealed the presence of fixed oils, phytosterols, gums, mucilage, alkaloids, carbohydrates, saponins, proteins and volatile oil. CCl4 induced hepatic damage was evident from the altered levels of biochemical markers like Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP), total bilirubin and total protein in CCl4 treated groups. Ethanol and aqueous extract treated groups significantly reduced the SGOT, SGPT, ALP, total bilirubin and increased the total protein levels which were adversely affected in the CCl4 treated group. The biochemical findings were supported by histopathological studies of the liver sections, which revealed the hepatotoxic nature of CCl4 and the protective potential of the extracts that is comparable with the standard drug silymarin.
Conclusion: This study reports the hepatoprotective potential of the rhizomes of S. roxburghiana Schult. & Schult. f.
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| Keyword:
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Murva, Hepatoprotection, S. roxburghiana, Carbon tetrachloride
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