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Synthesis and Anti-Cancer (Cytotoxic) Activity of Novel Thiazoloquinazolines Derivatives
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| Author:
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UPLOADED BY-ADMIN, PANNEER SELVAM T, VIJAYARAJ KUMAR P
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| Abstract:
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A series of 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline (6a-o)
have been synthesized to meet the structural requirements essential for anti-cancer properties. The synthesized series of heterocycles,
6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline (6a-o) by the
reaction of 6,7,8,9 Tetra hydro-5H-5- phenyl thiazolo (2, 3-b) quinazolin-3(2H)-one 3 with appropriate hydrazine hydrate
and ketones / aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid as presented in scheme. Their
anti-cancer activity was evaluated by MTT assay. The 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3- (N´-3-pentylidenehydrazino)
thiazolo (2, 3-b) quinazoline (6b) and 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-(N´-2-pentylidenehydrazino)
thiazolo (2, 3-b) quinazoline (6c) exhibited the most potent anti-cancer activity.
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| Keyword:
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Thiazolo quinazoline; Benzylidine thiazolo quinazoline, Anti-cancer activity.
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| EOI:
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| DOI:
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