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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Anti-Cancer (Cytotoxic) Activity of Novel Thiazoloquinazolines Derivatives

Author: UPLOADED BY-ADMIN, PANNEER SELVAM T, VIJAYARAJ KUMAR P
Abstract: A series of 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline (6a-o) have been synthesized to meet the structural requirements essential for anti-cancer properties. The synthesized series of heterocycles, 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline (6a-o) by the reaction of 6,7,8,9 Tetra hydro-5H-5- phenyl thiazolo (2, 3-b) quinazolin-3(2H)-one 3 with appropriate hydrazine hydrate and ketones / aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid as presented in scheme. Their anti-cancer activity was evaluated by MTT assay. The 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3- (N´-3-pentylidenehydrazino) thiazolo (2, 3-b) quinazoline (6b) and 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-(N´-2-pentylidenehydrazino) thiazolo (2, 3-b) quinazoline (6c) exhibited the most potent anti-cancer activity.
Keyword: Thiazolo quinazoline; Benzylidine thiazolo quinazoline, Anti-cancer activity.
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0.12
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