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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Preparation of solid self-Micro-emulsified lipid systems for the delivery of hydrophobic drugs

Abstract: Abstract: The field of solid dispersion as an approach to improve the dissolution characteristics and hence the bioavailability of poorly-water soluble drugs is known for more than 50 years yet, there are only few products on the market using this technology. The conversion of the drug administered in these systems from the amorphous metasatble state into the thermodynamically stable crystalline form on aging, and the low loading capacity of the carrier systems to the drug have limited development in these systems. Based on solid dispersion technology and self-emulsified lipid formulations, new solid carrier systems were developed in this investigation, which were identified as solid self-micro-emulsified drug delivery systems (S-SMEDDS). According to the type of solid carrier included and the class of lipid system, those new vehicles were classified into hydrophilic (h) and lipophilic (l) S-SMEDDS. The polymeric carrier PEG 10000 was included in a hydrophilic type III lipid class system to form h-S-SMEDDS, whereas carnauba wax was included in a lipophilic type II lipid class system to produce formulations of l-S-SMEDDS. Results obtained from XRD and DSC have shown that these new carrier systems have potential advantage of high loading capacity of drugs in the high energy amorphous state and are not susceptible to the aging processes. They can maintain the drug in the amorphous form without the propensity to nucleation and growth of crystals after storing for a long period.
Keyword: SMEDDS; S-SMEDDS; Solid dispersion; Lipid formulations; DSC and poorly water-soluble compounds.
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