IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Article Detail

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STABILITY INDICATING RP-HPLC METHODS FOR SIMULTANEOUS DETERMINATION OF AMLODIPINE AND PERINDOPRIL IN PHARMACEUTICAL FORMULATION IN THE PRESENCE OF THEIR DEGRADATION PRODUCTS

Author: GHANSHYAM SANGHANI, S S PANDYA, ASHOK AKABARI, USMANGANI CHHALOTIYA
Abstract: The specific, sensitive, and precise stability-indicating RP-HPLC method has been developed, optimized and validated for determination of amlodipine besylate (AML) and perindopril arginin (PER) in their mixtures and in the presence of their degradation products. The method was based on high-performance liquid chromatography, by which the proposed components were separated on a reversed-phase C18 analytical column using mobile phase composition of acetonitrile–0.025M potassium dihydrogen phosphate buffer (30 + 70, v/v) and pH 3.0 adjusted with orthophosphoric acid with ultraviolet detection at 271 nm. Different parameters affecting the suggested methods were optimized for maximum separation of the cited components. System suitability parameters of the developed methods were also tested. The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for the quantification of PER and AML in their commercial tablets.
Keyword: Amlodipine besylate (AML), Perindopril arginin (PER), RP-HPLC
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0.12
2018CiteScore
 
8th percentile
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477