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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Comparative Study on In-vitro Free Radical Scavenging Potential of Different Solvent Extracts of Morinda umbellata Linn. and its Quantitative Phytochemical Constituents

Author: KRISHNAKUMAR MOHANDAS, LATHA, SUJA, RAJASEKHARAN
Abstract: Morinda umbellata is an important medicinal liana distributed in South East Asia and on which very limited medicinal research has been conducted. It is an important traditional medicinal plant of India, China, Vietnam and Thailand. The present study is aimed to scientifically validate the free radical scavenging and antioxidant effects of different solvent extracts of Morinda umbellata Linn. leaves with different in vitro assays and also to estimate the total phenolic, flavonoid and condensed tannin contents in crude, n-hexane, chloroform, 10% aqueous ethanol and water extracts. A significantly higher total phenolic content was estimated in the crude ethanolic leaf extract of M. umbellata. Crude ethanolic and chloroform extracts possess significantly higher flavonoid and condensed tannin content. The crude ethanolic extract of M. umbellata leaves exhibited 65.88% inhibition against hydroxyl at 200 µg/ml dose. Other extracts did not show any significant activity against hydroxyl radicals. Scavenging of DPPH radicals by the crude ethanolic, chloroform and n-hexane extracts (25 µg/ml) was significant compared to the standard ascorbic acid. In nitric oxide radical scavenging assay, all the extracts except the water extract showed potent activity against free radicals. In superoxide radical scavenging assay the maximum activity was exhibited by the n-hexane extract compared to ascorbic acid control. The antioxidant and free radical scavenging effects may be attributed to the high phenolic content and flavonoids present in the extracts, which further substantiates its traditional claim.
Keyword: Antioxidant, free radicals, flavonoids, DPPH, superoxide, polyphenols
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