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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Protective Activity of Saccharum officianarum Against CCl4 Induced Hepatotoxicity in Rats

Author: UPLOADED BY-ADMIN, PATEL BA, PATEL JD, RAVAL BP, GANDHI TR
Abstract: ml/kg, i. p.) once daily for seven days. Saccharum officinarum juice (0.75ml/100gm, P.O.) was given for seven days. Silymarin (200mg/kg, p. o) was used as a reference drug. Levels of different marker enzymes were estimated in serum. A probe into the mechanism of action was attempted by estimating total protein, malondialdehyde and glutathione levels in liver homogenates in order to evaluate the degree of lipid peroxidation. Histopathological studies were also done to confirm the biochemical changes. In vitro, Hepatocytes of control group were exposed to CCL4, while cell suspensions were pretreated with S. officianrum (1mg/ml) before exposure to CCL4 and standard group received silymarin (1mg/ml) before exposure to CCL4. While in vitro model, estimation of percentage viability of hepatocytes was evaluated by trypan blue assay. CCl4 produced significant changes in physical (increased liver weight and volume), biochemical (increase in serum alanine transaminase, aspartate transaminase, alkaline phosphatase, direct bilirubin, total bilirubin and triglycerides), liver tissue (decreased totoal protein, GHS and increased MDA), histological (hepatocytes damage) and functional (thiopentone induced sleeping time) liver parameters. Treatment with S. officinarum stem juice significantly prevented the physical, biochemical, histological and functional changes induced by ethanol in the liver, while in vitro model exhibited significant increase in percentage viability of cells with preexposure to S.officinarum and Silymarin as compared to CCl4 control. Juice of S. officinarum exhibited significant hepatoprotective action against CCl4 induced hepatic injury both in vivo and in vitro study.
Keyword: CCl4, hepatoprotective activity, juice, Saccharum officinarum, antioxidant.
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