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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Transbuccal delivery of antidiabetic drug through egg shell membrane as a model substrate

Author: NISHA SINGH, ROSHAN ISSARANI, B. P NAGOI
Abstract: The aim of the present investigation was to develop and evaluate buccoadhesive gel of an antidiabetic drug to maintain its bioavailability over an extended period of time and to circumvent the hepatic first pass effect. Glipizide was selected as model drug for preparing buccoadhesive gels, which showed maximum solubility at pH 9.0. Prepared buccoadhesive gel of glipizide using different polymers at different ratios in different pH were evaluated for various parameters namely viscosity and buccoadhesive strength. Gels of pH 6.8 were rejected on the basis of least viscosity and buccoadhesive strength respectively. The selected gels of pH 7.4 were evaluated for swelling index, drug content and drug release. The maximum swelling index was found for the combination of CP and SCMC at the ratio 1:3, drug content was found in the range of 92.6% to 97.4%. Formulation CPH2 showed sustained drug release (t50% - >6 hrs.)and was further selected to observe the effect of permeation enhancer.
Keyword: Buccoadhesive gel, Glipizide, egg shell membrane, transbuccal
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