IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
An Efficient, Simple and Convenient Process for the Synthesis of Two Imatinib Mesylate Impurities and Spectral Characterization

Author: CHAMARTHI RAJU, MANDALA CHANDRASHEKAR, AJAT SHATRU, NEERAJ KUMAR, KALLURI SESHAIAH, CHAMARTHI NAGA RAJU
Abstract: Imatinib Mesylate (1) is an endured powerful drug used for the treatment of multiple cancers. Several possibilities are conceivable for the formation of impurities in the process of synthesis of active pharmaceutical ingredients. In the processes development of Imatinib Mesylate, we have found impurities and two of them were identified as N-[4-methyl-3-(4-methyl-3-yl-pyrimidin-2-ylamino)-phenyl]-4- chloromethyl benzamide (5) (Impurity-I genotoxic impurity) and 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl] amino] phenyl]-benzamide (7) (Impurity-II). In the present study, we developed a simple, efficient and convenient method for the synthesis of two impurities of Imatinib Mesylate using starting materials, 4-methyl benzoic acid (2) and 6-methyl-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine (4) with simple workup procedure followed purification and recrystallization. The structures of the impurities were characterized by IR, NMR (1H and 13C), LC-mass and HPLC analysis.
Keyword: Imatinib Mesylate, Anti-cancer drug, Impurities, Genotoxic impurity, 4-methyl benzoic acid.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
A BRIDGE BETWEEN PHARMACEUTICAL ANALYSIS & REGULATORY AFFAIRS

National Conference in collaboration with GTU on 06.07.2019 at SNLPCP, Umrakh

Download Brochure
News & Events
Google Scholar

hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus
Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477