IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Article Detail

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Formulation and Characterization of Rutin trihydrate Liposomes for Topical Delivery

Author: APARAJITA VARSHNEYA, PADMINI RAVIKUMAR
Abstract: In the present study, liposomes were formulated as drug carriers for enhancing the delivery of an antioxidant Rutin trihydrate for topical administration. Formulation of liposomes was done by thin film hydration method. Optimization was achieved by varying the lipid to cholesterol ratio and gradually increasing the amount of drug until maximum entrapment efficiency was achieved. The formulation and process parameters were optimized to attain multilamellar liposomes with homogeneous size and good entrapment. The optimized batch gave entrapment efficiency of 88%. Gels were prepared by using Carbopol 940 as the gelling agent. The in vitro and ex vivo release profile of liposomal gels was compared with conventional gel formulations. The liposomal gel showed prolonged drug release upto 12 h and also exhibited anti-elastase activity. The safety of liposomal gels was ensured by conducting skin irritation studies on albino Wistar rats.
Keyword: Liposomes, Rutin trihydrate, topical delivery, gels.
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477