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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Characterization of Rutin trihydrate Liposomes for Topical Delivery

Author: APARAJITA VARSHNEYA, PADMINI RAVIKUMAR
Abstract: In the present study, liposomes were formulated as drug carriers for enhancing the delivery of an antioxidant Rutin trihydrate for topical administration. Formulation of liposomes was done by thin film hydration method. Optimization was achieved by varying the lipid to cholesterol ratio and gradually increasing the amount of drug until maximum entrapment efficiency was achieved. The formulation and process parameters were optimized to attain multilamellar liposomes with homogeneous size and good entrapment. The optimized batch gave entrapment efficiency of 88%. Gels were prepared by using Carbopol 940 as the gelling agent. The in vitro and ex vivo release profile of liposomal gels was compared with conventional gel formulations. The liposomal gel showed prolonged drug release upto 12 h and also exhibited anti-elastase activity. The safety of liposomal gels was ensured by conducting skin irritation studies on albino Wistar rats.
Keyword: Liposomes, Rutin trihydrate, topical delivery, gels.
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0.12
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