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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Spectrophotometric Estimation of Roxithromycin in Bulk and Pharmaceutical Preparation

Author: UPLOADED BY-ADMIN, PATEL P. J, DERASARI J. M, PATEL V.B.
Abstract: A simple and sensitive spectrophotometric method has been developed for determination of roxithromycin in its pharmaceutical dosage forms. In the proposed method, roxithromycin is hydrolysed in the presence of 3.6M hydrochloric acid in acetic acid medium and p-dimethylaminobenzaldehyde to form a blue-coloured chromogen with absorption maxima at 485 nm. The method is found to be linear in the concentration range of 5- 50 µg/ml with regression coefficient of 0.9987. The method was validated and can be used successfully to assay roxithromycin in its pharmaceutical dosage form, viz, tablets.
Keyword: Spectrophotometric, Roxithromycin, p-dimethylaminobenzaldehyde
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0.12
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