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Solubilization: A Bane for Anti-malarial Drugs
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| Author:
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SNEHA SAWANT, PRAMOD KADU, SWETA SAVLA, VISHAL ROKADE , ANKITA SURJUSE
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| Abstract:
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Dissolution of drug is the rate determining step for oral absorption of the poorly water soluble drugs and solubility is a significant physicochemical factor affecting absorption of drug. However it has been observed that in case of drugs which have poor water solubility, bioavailability is hampered. Hence to enhance the solubility of these drugs various approaches are employed which further help to improve the bioavailability and promote therapeutic efficacy. Malaria is considered to be one of the leading causes of death around the world. Hence anti-malarial drugs need to have good bioavailability which would enhance the therapeutic efficacy of drugs. For enhancement of solubility and dissolution rate of poorly soluble drugs, abundant commercially available methods are available which include solid dispersion, cyclodextrin encapsulation, lipid based drug delivery system, nanosuspension and micronization. Selection of solubility enhancement method depends on properties of drug, their site of absorption in the body, and required characteristics of dosage form based on potency of drug.
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| Keyword:
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Solubility, bioavailability, malaria, solid dispersion, cyclodextrin, nanosuspension, micronization, microemulsion
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| DOI:
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