IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Solubilization: A Bane for Anti-malarial Drugs

Author: SNEHA SAWANT, PRAMOD KADU, SWETA SAVLA, VISHAL ROKADE , ANKITA SURJUSE
Abstract: Dissolution of drug is the rate determining step for oral absorption of the poorly water soluble drugs and solubility is a significant physicochemical factor affecting absorption of drug. However it has been observed that in case of drugs which have poor water solubility, bioavailability is hampered. Hence to enhance the solubility of these drugs various approaches are employed which further help to improve the bioavailability and promote therapeutic efficacy. Malaria is considered to be one of the leading causes of death around the world. Hence anti-malarial drugs need to have good bioavailability which would enhance the therapeutic efficacy of drugs. For enhancement of solubility and dissolution rate of poorly soluble drugs, abundant commercially available methods are available which include solid dispersion, cyclodextrin encapsulation, lipid based drug delivery system, nanosuspension and micronization. Selection of solubility enhancement method depends on properties of drug, their site of absorption in the body, and required characteristics of dosage form based on potency of drug.
Keyword: Solubility, bioavailability, malaria, solid dispersion, cyclodextrin, nanosuspension, micronization, microemulsion
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0.12
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477