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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Method development and validation for estimation of Pirfenidone by UV-Spectrophotometric and RP-HPLC in tablet dosage form

Author: KESHA DESAI, ALISHA PATEL, DR BHAVESH PATEL, KESHA DESAI
Abstract: UV Spectrophotometric and Reverse Phase High Performance Liquid Chromatography (RP-HPLC) methods have been developed for estimation of Pirfenidone in tablet dosage form. First UV spectrophotometric method was a determination of drug at 311 nm over the concentration range 16-32 µg/ml with accuracy 98.08-100.62%. % CV for repeability, intraday and interday precision was found to be less than 2. LOD and LOQ were found to be 2.48 and 7.44 respectively. In RP-HPLC analysis carried out using methanol: water (80:20 v/v) as the mobile phase and Hypersil column with detection wavelength of 311 nm. Flow rate was 1 ml/min. Retention time for pirfenidone was 3.952 min. Linearity was obtained in the concentration range of 2-12 µg/ml with accuracy 99.08-100.44%. %CV for repeability, intraday and interday precision was found to be less than 2. LOD and LOQ were found to be 0.18 and 0.54 respectively. Developed methods are simple, accurate, sensitive and specific and they can be used for the estimation of pirfenidone in tablet dosage form.
Keyword: Pirfenidone, UV spectrophotometric, RP-HPLC
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