IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Method development and validation for estimation of Pirfenidone by UV-Spectrophotometric and RP-HPLC in tablet dosage form

Author: KESHA DESAI, ALISHA PATEL, DR BHAVESH PATEL, KESHA DESAI
Abstract: UV Spectrophotometric and Reverse Phase High Performance Liquid Chromatography (RP-HPLC) methods have been developed for estimation of Pirfenidone in tablet dosage form. First UV spectrophotometric method was a determination of drug at 311 nm over the concentration range 16-32 µg/ml with accuracy 98.08-100.62%. % CV for repeability, intraday and interday precision was found to be less than 2. LOD and LOQ were found to be 2.48 and 7.44 respectively. In RP-HPLC analysis carried out using methanol: water (80:20 v/v) as the mobile phase and Hypersil column with detection wavelength of 311 nm. Flow rate was 1 ml/min. Retention time for pirfenidone was 3.952 min. Linearity was obtained in the concentration range of 2-12 µg/ml with accuracy 99.08-100.44%. %CV for repeability, intraday and interday precision was found to be less than 2. LOD and LOQ were found to be 0.18 and 0.54 respectively. Developed methods are simple, accurate, sensitive and specific and they can be used for the estimation of pirfenidone in tablet dosage form.
Keyword: Pirfenidone, UV spectrophotometric, RP-HPLC
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2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477