*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *         Journal is Currently Not Indexed in Scopus as on february 2021 list Updated by scopus

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, Characterization and Antimicrobial Activity of Benzimidazolyl-Phenothiazine De-rivatives

Author: UPLOADED BY-ADMIN, SHARAD KUMAR, V.D. GUPTA, A.K. SETH, YOGESH CHAND YADAV, UJJWAL SAHOO, TEJASK GHELANI, ASHIM KUMAR SEN, DHANYAB.
Abstract: Ten Novel compounds have been synthesized combining Phenothiazine ring and Benzimidazole. Phenothiazine (I) was synthesized by reacting diphenylamine, sulfur, and iodine which subsequently reacted with p-amino benzoic acid and aromatic aldehydes in ethanol produces 10-(a-p-carboxyphenylaminobenzyl) phenothiazines (II). Phenothiazines (II) was further treated with o-phenylene diamine in pyridine resulted in the formation of 10-(a-p-benzimidazolyl aminobenzyl) phenothiazines (III). A Series of compounds like N-((2-(4-((10H-phenothiazin-10-yl) (phenyl) methyl amino) phenyl)-1H-benzo[d]imidazol- 1-yl)(phenyl) methyl) benzamine (IVa-j) were synthesized by refluxing intermediate compound III with different amines in presence of ethanol. The yield of novel compound was recorded 27-56%. All compounds were characterized on the basis of melting point, I.R spectra, N.M.R spectra and mass spectra to establish their molecular weight, formula. The antimicrobial activity of novel synthesized compounds was evaluated by Disc- Diffusion method. Products IVc, IVf, and IVg showed better, while IVd, and IVe showed moderate and rest showed poor antimicrobial activity.
Keyword: Phenothiazines, Benzimidazole, Benzamine
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