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Synthesis, Characterization and Antimicrobial Activity of Benzimidazolyl-Phenothiazine De-rivatives
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UPLOADED BY-ADMIN, SHARAD KUMAR, V.D. GUPTA, A.K. SETH, YOGESH CHAND YADAV, UJJWAL SAHOO, TEJASK GHELANI, ASHIM KUMAR SEN, DHANYAB.
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| Abstract:
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Ten Novel compounds have been synthesized combining Phenothiazine ring and Benzimidazole. Phenothiazine
(I) was synthesized by reacting diphenylamine, sulfur, and iodine which subsequently reacted
with p-amino benzoic acid and aromatic aldehydes in ethanol produces 10-(a-p-carboxyphenylaminobenzyl)
phenothiazines (II). Phenothiazines (II) was further treated with o-phenylene diamine in pyridine
resulted in the formation of 10-(a-p-benzimidazolyl aminobenzyl) phenothiazines (III). A Series of
compounds like N-((2-(4-((10H-phenothiazin-10-yl) (phenyl) methyl amino) phenyl)-1H-benzo[d]imidazol-
1-yl)(phenyl) methyl) benzamine (IVa-j) were synthesized by refluxing intermediate compound III with
different amines in presence of ethanol. The yield of novel compound was recorded 27-56%. All compounds
were characterized on the basis of melting point, I.R spectra, N.M.R spectra and mass spectra to
establish their molecular weight, formula. The antimicrobial activity of novel synthesized compounds was
evaluated by Disc- Diffusion method. Products IVc, IVf, and IVg showed better, while IVd, and IVe
showed moderate and rest showed poor antimicrobial activity.
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| Keyword:
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Phenothiazines, Benzimidazole, Benzamine
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