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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Reduction of Cisplatin Toxicity in Vero Cell Lines by Pedalium murex Linn. Leaf Extract

Author: I ALAM, V GOPAL, C VASANTHI, P K MANNA
Abstract: Nephrotoxicity is the damage/destruction of kidney function by exogenous or endogenous toxicants. Drug induced nephrotoxicity is a common problem in many vital treatments. Cisplatin is highly effective to broad spectrum of malignancies, its adverse effect of nephrotoxicity limits its use. Pedalium murex is an annual herb with wide range of phytoconstituents and pharmacological activity. In this research work it was aimed to reveal the nephroprotective property of leaf of Pedalium murex. Different extracts of P. murex leaf was subjected to DPPH, ABTS & NO antioxidant assay and in-vitro nephroprotective activity on vero cell lines. Cytotoxicity was induced by Cisplatin and the cell viability was studied by MTT assay. Among the different extracts, aqueous(PLW) and ethanolic(PLE) extracts exhibited good DPPH scavenging activity than chloroform and n-hexane extracts with IC50 value of 21.14±2.65 µg/ml and 16.18±0.79 µg/ml respectively. Whereas for gallic acid IC50 was 3.19±2.33 µg/ml. In ABTS and NO assay PLE showed significantly more scavenging property than PLW. Total phenolic content in PLE (61.18±2.36 mg GAE/g) was more than PLW (36.80±1.86 mg GAE/g). In-vitro nephroprotectie analysis revealed that PLE possess more nephroprotective with percentage cell viability of 96.93±1.04% than PLW with 86.65±1.87% at 200µg/ml concentration. Standard drug Quercetin showed 90.68±0.11% cell viability at 100µg/ml. The results indicates that ethanolic extract of Pedalium murex effectively reduces cisplatin toxicity in cultured vero cells. The scavenging of free radicals may be the important role in the protection, as reactive oxygen species (ROS) generation and oxidative stress is the major reason for cisplatin nephrotoxicity.
Keyword: Nephroprotective, Cisplatin, Vero cells, Nephrotoxicity, Pedalium murex, cytotoxicity
DOI: https://doi.org/10.31838/ijpr/2019.11.02.058
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477