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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and fungicidal activity of substituted 1-[(1,3-dioxolan-4-yl)]methyl-1H-imidazoles and 1-[(1,3-dioxolan-4-yl)methyl]-1H-1,2,4-triazoles based on arylidene ketones

Author: V.S. TALISMANOV, S.V. POPKOV, O.G. KARANOVA, S.S. ZYKOVA
Abstract: Chloromethyldioxolanes were synthesized on the basis of arylidene ketones obtained by condensation of ketones with aldehydes. The interaction of chloromethyldioxolanes with 1,2,3-triazole or imidazole resulted in the substituted 1-[(1,3-dioxolan-4-yl)]methyl-1H-imidazoles, 1-[(1,3-dioxolan-4-yl)methyl]-1H-1,2,4-triazoles.In vitro tests of substituted compounds showed high fungicidal activity against six common fungal phytopathogens: Sclerotinia sclerotiorum, Fusarium oxysporum, Fusarium moniliforme, Bipolaris sorokiniana, Rhizoctonia solani and Venturia inaequalis.
Keyword: alkylation, 1,3-dioxolane, imidazole, fungicidal activity, ketalization, ketals, 1,2,4-triazole.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.051
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0.12
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