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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Safety Studies of Bisehri Booti (Aerva lanata Linn.)–A Frequently used Unani Medicinal plant as medicament

Author: NAJMUDDIN SIDDIQUI, ASMA ABID, MOHAMMAD ZAKIR, MASROOR ALI QURESHI, AMIR AZAM
Abstract: WHO has made it mandatory to do safety studies of herbal medicines and food items in order to prevent the possible toxicity caused by the contamination of toxic materials found in the soils. The aim of the present study was to determine the concentration of aflatoxin, heavy metal, pesticidal residue, microbial load in the market sample of the Bisehri Booti (Aerva lanata L.) and cytotoxicity study was also conducted. Load Determination Test for each contaminant was done to determine the load of specific contaminants in test drug. The total Bacterial and yeast Count was determined using plate count method for bacteria, fungi and specific pathogens. LCMS-MS was used to find presence of aflatoxins e.g. Aflatoxins B1, aflatoxins G1, aflatoxin B2 and aflatoxin G2. GCMS-MS was used to determine the Specific pesticide residues such as organo-chlorine, organo-phosphorous and Pyrethroids compounds. Heavy metals including Arsenic, Mercury, Cadmium and Lead were determined by using AAS technique. Cytotoxicity study of the normal cells eg. HEK293 was evaluated with the help of MTT assay. Bisehri Booti (Aerva lanata L.) was found to possess aflatoxin, pesticidal residue and microbial but well below the permissible limits, while the heavy metals were quietly absent and more than 75% cells were viable even at 250 µg/ml concentration of extracts. The results concluded that market sample is safe and may be used as a therapeutic agent.
Keyword: Cytotoxicity, Safety Profile, Bisehri Booti, WHO guidelines, Heavy metals
DOI: https://doi.org/10.31838/ijpr/2019.11.02.049
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