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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The inflammatory response to resistance training and the expression of Toll-like receptor-4 gene impact in elderly women

Author: RAWAA ALFATLAWI, TAGHREED DHEYAA ALJAZAERI, MUROOJ L. MAJEED, NAJAH R HADI
Abstract: Our study evaluate the effects of a resistance training scheme on the inflammationassociated with Toll-like receptor-4 expression in elderly women. Twenty healthy female (age, 60-70) were voluntarily participated,part of them were subjected as a Training (TG; n=10), while the other parte were subjected a control (CG; n=10) group. TGperformed a10-week resistance training program, whenCG followed theirordinary habit. sampleswere obtained from Peripheral blood before and after the process, and levelsof TLR4expression obtained by Real time qPCR applied inthis experiment utilized the SYBR green ,a fluorescent dye thatrecognizes any ds DNA including cDNA.The inflammatory response was assessed throughmeasuring serum content of interleukinIL-10 and IL-6and C-reactive protein (CRP). After the10-week exercise training, TLR4expression was decrease in TG after the intervention. While IL-6 protein values staynot changed in both TG and CG, IL-10 protein content were increased inTG after theintervention. However CRP values reduce in TGonly. The increase in IL-10 negatively coordinate with TLR4 down regulation. These data proposethat resistance training may give rise toimprove the pro-inflammatory condition of old womenthrough deficiency of TLR4 expression.
Keyword: Inflammation, resistanceexercise,elderly, TLR.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.046
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