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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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The inflammatory response to resistance training and the expression of Toll-like receptor-4 gene impact in elderly women

Author: RAWAA ALFATLAWI, TAGHREED DHEYAA ALJAZAERI, MUROOJ L. MAJEED, NAJAH R HADI
Abstract: Our study evaluate the effects of a resistance training scheme on the inflammationassociated with Toll-like receptor-4 expression in elderly women. Twenty healthy female (age, 60-70) were voluntarily participated,part of them were subjected as a Training (TG; n=10), while the other parte were subjected a control (CG; n=10) group. TGperformed a10-week resistance training program, whenCG followed theirordinary habit. sampleswere obtained from Peripheral blood before and after the process, and levelsof TLR4expression obtained by Real time qPCR applied inthis experiment utilized the SYBR green ,a fluorescent dye thatrecognizes any ds DNA including cDNA.The inflammatory response was assessed throughmeasuring serum content of interleukinIL-10 and IL-6and C-reactive protein (CRP). After the10-week exercise training, TLR4expression was decrease in TG after the intervention. While IL-6 protein values staynot changed in both TG and CG, IL-10 protein content were increased inTG after theintervention. However CRP values reduce in TGonly. The increase in IL-10 negatively coordinate with TLR4 down regulation. These data proposethat resistance training may give rise toimprove the pro-inflammatory condition of old womenthrough deficiency of TLR4 expression.
Keyword: Inflammation, resistanceexercise,elderly, TLR.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.046
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477